A comprehensive review of the natural history of Helicobacter pylori infection in children.

摘要: Across populations of children, Helicobacter pylori prevalence ranges from under 10% to over 80%. Low occurs in the U.S., Canada, and northern western Europe; high India, Africa, Latin America, eastern Europe. Risk factors include socioeconomic status, household crowding, ethnicity, migration regions, infection status family members. H. is not associated with specific symptoms children; however, it consistently antral gastritis, although its clinical significance unclear. Duodenal ulcers are seldom seen children 10 years age. pylori-infected demonstrate a chronic, macrophagic, monocytic inflammatory cell infiltrate lack neutrophils, as compared response observed adults. The effect on acid secretion remains poorly defined. events that occur during colonization should be studied more thoroughly urease activity, motility, chemotaxis, adherence, downregulation host response. importance virulence determinants described relevant for disease has been extensively children. Highly sensitive methods detection needed, especially younger pediatric which early phases. Criteria use eradication treatment need established. Multicenter studies focus identification risk factors, can used prognostic indicators development gastroduodenal later life.