Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits.

摘要: Objectives. We evaluated the influence of passive smoking on experimental atherosclerosis in cholesterol-fed rabbits. Background. Exposure to environmental tobacco smoke (ETS) has been epidemiologically linked death from ischemic heart disease nonsmokers. Methods. New Zealand male rabbits were randomly divided into three groups after 2 weeks a 0.3% cholesterol diet. Sixteen exposed high and 16 low dose ETS; 32 located another room served as an unexposed control group. After 10 ETS exposure, all killed, percent aortic pulmonary artery endothelial surfaces covered by lipid lesions was measured staining planimetry. Results. Average air nicotine, carbon monoxide total pariculate concentrations 1,040 μg/m3, 60.2 ppm 32.8 mg/m3for group, 30 18.8 4.0 group <1 3.1 0.13 The atherosclerotic involvement aorta increassd significantly with exposure (for aorta, ± 19% [mean SD] for 36 14% 52 11% p < 0.001; artery, 22 15% 29 25% 45 12% 6.031). Bleeding time shorter two than (86 17 vs. 68 15, 18 s, 0.001). There no significant differences serum triglycerides, density lipoprotein at end study. Conclusions. Environmental affects platelet function increases palmonary atherosclerosis. This increase independent changes lipids exhibited dose-response relation. These results are consistent data epidemiologic studies demonstrating that risk due disease.