Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response.

摘要: INTRODUCTION In the course of evolution, multicellular organisms have developed immune mechanisms that protect them from predations unicellular life forms. The most fundamental attribute any system is its ability to distinguish self non-self. Beyond this, an must be able recognize a wide diversity would-be pathogens if it effective. general, has "sensing" (afferent) [...]