Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application

摘要: Abstract Background: Since the introduction in 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new have improved efficacy, persistence, or significantly use characteristics not been forthcoming. In addition, manufacturer's labeling for popular products generally requires times excess 6 minutes, whereas current practical needs call with substantially shorter times. A alcohol-based formulation, which has ingredients provide emollient, surfactant, and antimicrobial persistence to complement rapid broad-spectrum antiseptic qualities alcohol, developed an effort address these needs. Methods: The relative efficacy a formulation contains surfactant was compared commercial CHG 7.5% povidone iodine (PVPI) human subjects. Hand count sampling performed by using standardized "glove juice" methodology. Results: results showed statistically significant improvement over both PVPI at lessened time (3 minutes). without brush produced similar 3-minute applications either sponge. Conclusions: demonstrates promise as are formulations. These studies demonstrate suitability this brushless application. (AJIC Am J Infect Control 1998;26:507-12)