Immuno-Modulatory Role of Porins: Host Immune Responses, Signaling Mechanisms and Vaccine Potential
作者： Sanica C. Sakharwade , G. V. R. Krishna Prasad , Arunika Mukhopadhaya
DOI: 10.1007/978-3-319-11280-0_6
关键词: Virology 、 Pathogen-associated molecular pattern 、 Bacteria 、 Immune system 、 Beta barrel 、 Cell biology 、 Pattern recognition receptor 、 Bacterial outer membrane 、 Chemistry 、 Signal transduction 、 Genome
摘要: The outer membrane of gram-negative bacteria allows the to survive amidst harsh conditions and is crucial for its interaction with environment. consists proteins LPS. protein content contributes up 50 % total mass whole bacterium. Further, about one-third genome encodes proteins. These are beta barrel in structure perform various roles apart from providing structural stability. They can help transport substances, signal transduction, adherence invasion, enzymatic reactions, as well act PAMPs (pathogen associated molecular patterns) which be recognized by PRRs (pattern recognition receptors) present on host immune cells. Porins a class that aid substances across membrane. This review highlights role porins immuno-modulatory processes, signaling mechanisms they activate cells their use vaccines against bacterial infections.
springer.com
sci-hub.se 参考文章(143)
Sudhir Gupta, Dinender Kumar, Harpreet Vohra, Nirmal Kumar, Involvement of signal transduction pathways in Salmonella typhimurium porin activated gut macrophages. Molecular and Cellular Biochemistry. ,vol. 194, pp. 235- 243 ,(1999) , 10.1023/A:1006971621653
Hui Lü, Hong Wang, Hong-Mei Zhao, Lei Zhao, Qiang Chen, Mei Qi, Juan Liu, Han Yu, Xiu-Ping Yu, Xi Yang, Wei-Ming Zhao, None, Dendritic cells (DCs) transfected with a recombinant adenovirus carrying chlamydial major outer membrane protein antigen elicit protective immune responses against genital tract challenge infection. Biochemistry and Cell Biology. ,vol. 88, pp. 757- 765 ,(2010) , 10.1139/O10-011
Constantino Roberto Lopez-Macias, Denis Leclerc, Compositions Comprising Salmonella Porins and Uses Thereof as Adjuvants and Vaccines ,(2009)
Madhubanti Sarkar, Swati Bhowmick, Antonella Casola, Keya Chaudhuri, Interleukin-8 gene regulation in epithelial cells by Vibrio cholerae: role of multiple promoter elements, adherence and motility of bacteria and host MAPKs. FEBS Journal. ,vol. 279, pp. 1464- 1473 ,(2012) , 10.1111/J.1742-4658.2012.08539.X
Jiun-Han Chen, Yung-Chung Lin, Yu-Kuo Tsai, Yip-Mei Liu, Chih-Hsiang Leng, Chang-Phone Fung, Pele Choi-Sing Chong, Hsin-Wei Chen, Shih-Jen Liu, Leung-Kei Siu, Feng-Yee Chang, Use of outer membrane porin k36 protein (ompk36) in treatment/prevention/diagnosis of enterobacteriaceae infection ,(2012)
Mariateresa Vitiello, Emiliana Finamore, Marco Cantisani, Paolo Bevilacqua, Novella Incoronato, Annarita Falanga, Emilia Galdiero, Marilena Galdiero, P2 porin and loop L7 from Haemophilus influenzae modulate expression of IL-6 and adhesion molecules in astrocytes Microbiology and Immunology. ,vol. 55, pp. 347- 356 ,(2011) , 10.1111/J.1348-0421.2011.00318.X
Myriam A Armant, Matthew J Fenton, Toll-like receptors: a family of pattern-recognition receptors in mammals Genome Biology. ,vol. 3, pp. 1- 6 ,(2002) , 10.1186/GB-2002-3-8-REVIEWS3011
Tamara Al-Bader, Keith A. Jolley, Holly E. Humphries, Judith Holloway, John E. Heckels, Amanda E. Semper, Peter S. Friedmann, Myron Christodoulides, Activation of human dendritic cells by the PorA protein of Neisseria meningitidis. Cellular Microbiology. ,vol. 6, pp. 651- 662 ,(2004) , 10.1111/J.1462-5822.2004.00392.X
Arunava Bandyopadhaya, Madhubanti Sarkar, Keya Chaudhuri, Transcriptional upregulation of inflammatory cytokines in human intestinal epithelial cells following Vibrio cholerae infection. FEBS Journal. ,vol. 274, pp. 4631- 4642 ,(2007) , 10.1111/J.1742-4658.2007.05991.X
Theresa E. Singleton, Paola Massari, Lee M. Wetzler, Neisserial Porin-Induced Dendritic Cell Activation Is MyD88 and TLR2 Dependent Journal of Immunology. ,vol. 174, pp. 3545- 3550 ,(2005) , 10.4049/JIMMUNOL.174.6.3545