Nephrotoxicity of nonionic low-osmolality versus ionic high-osmolality contrast media: a prospective double-blind randomized comparison in human beings.

摘要: To test whether a nonionic, low-osmolality contrast medium (iopamidol) administered for coronary angiography was less harmful to renal function than ionic, high-osmolality (sodium diatrizoate), prospective, double-blind randomized study of 70 patients with normal or mildly depressed (serum creatinine < = 2.0 mg/dL (175 mumol/L) performed. Creatinine clearance determined before and 24 48 hours after. There were no significant differences between the low- groups regard age, baseline clearance, dose given. In receiving (n 35), decreased by 19% +/- 13 (1 standard deviation) at recovered hours. 40% 16 remained 47% 14 function, use ...