Vaginal microbicides save money: a model of cost-effectiveness in South Africa and the USA.

摘要: Objective To determine the hypothetical cost-effectiveness of vaginal microbicides preventing male to female HIV transmission. Methods A mathematical epidemiological and model using data from South Africa USA was used. The prospective 1-year-long intervention targeted a general population women in city 1 000 000 inhabitants two very different settings, with prevalence 18.80% 0.72%. base case scenario assumes microbicide effective at 55%, used 30% sexual episodes retail price for public sector US$0.51 per use US$2.23 use. Results In Africa, over 1 year, would prevent 1908 infections, save US$6712 infection averted as compared antiretroviral treatment. USA, it be more costly: 21 amounting net cost US$405 077. However, setting Washington DC, higher prevalence, same 93 infections US$91 176 averted. Sensitivity analyses were conducted even low effectiveness still healthcare costs Africa. Conclusions is likely cost-effective country undergoing high-level generalised epidemic such but unlikely developed presenting features similar unless exceeds 2.4%.