Paraoxonase (PON1), detoxification of nerve agents, and modulation of their toxicity
作者： Lucio G. Costa , Toby B. Cole , Jacqueline Garrick , Judit Marsillach , Clement E. Furlong
DOI: 10.1016/B978-0-12-819090-6.00070-2
关键词: Paraoxon 、 PON1 、 Toxicity 、 Nerve agent 、 Pharmacology 、 Acute toxicity 、 Paraoxonase 、 Soman 、 Sarin 、 Chemistry
摘要: Abstract Paraoxonase (PON1) is a serum and liver enzyme that can hydrolyze in vitro several organophosphorus (OP) compounds, including the active metabolites of specific OP insecticides, certain nerve agents such as sarin soman. PON1 presents genetic polymorphisms influence its ability to OPs well level expression. Studies animals, transgenic mice, have shown modulates vivo acute toxicity OPs, chlorpyrifos oxon diazoxon. In contrast, because low catalytic efficiency toward paraoxon, does not this vivo. The similarly low, though some studies administration exogenous protect against soman sarin. For use bioscavengers, recombinant engineered PON1s need be developed with an enhanced being devoid immunogenicity. Such would excellent candidates for prophylactic therapeutic applications case agent poisoning. A parallel strategy identifying studying which increase levels endogenous PON1.
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