Weapons of Microbial Drug Resistance Abound in Soil Flora

作者: Alexander Tomasz

DOI: 10.1126/SCIENCE.1123982

关键词: Drug resistanceBiotechnologyMicrobial drug resistanceBacteriaSoil microbiologyBiologyDNA Transposable ElementsAntibioticsFlora (microbiology)

摘要: Bacteria found in soils show robust resistance to many antibiotics. These protective mechanisms may offer clues for generating a new arsenal of therapeutic drugs.

参考文章(11)
Arnold L. Demain, Aiqi Fang, The natural functions of secondary metabolites. Advances in Biochemical Engineering \/ Biotechnology. ,vol. 69, pp. 1- 39 ,(2000) , 10.1007/3-540-44964-7_1
Marta Aires de Sousa, Hermínia Lencastre, Bridges from hospitals to the laboratory: genetic portraits of methicillin-resistant Staphylococcus aureus clones. Fems Immunology and Medical Microbiology. ,vol. 40, pp. 101- 111 ,(2004) , 10.1016/S0928-8244(03)00370-5
Linda M Weigel, Don B Clewell, Steven R Gill, Nancye C Clark, Linda K McDougal, Susan E Flannagan, James F Kolonay, Jyoti Shetty, George E Killgore, Fred C Tenover, Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus Science. ,vol. 302, pp. 1569- 1571 ,(2003) , 10.1126/SCIENCE.1090956
Anatoly Severin, Keiko Tabei, Fred Tenover, Marilyn Chung, Nancy Clarke, Alexander Tomasz, High level oxacillin and vancomycin resistance and altered cell wall composition in Staphylococcus aureus carrying the staphylococcal mecA and the enterococcal vanA gene complex. Journal of Biological Chemistry. ,vol. 279, pp. 3398- 3407 ,(2004) , 10.1074/JBC.M309593200
János Bérdy, Bioactive microbial metabolites. The Journal of Antibiotics. ,vol. 58, pp. 1- 26 ,(2005) , 10.1038/JA.2005.1
W. WITTE, I. KLARE, Glycopeptide-Resistant Enterococcus faecium Outside Hospitals: A Commentary Microbial Drug Resistance. ,vol. 1, pp. 259- 263 ,(1995) , 10.1089/MDR.1995.1.259
Vanessa M D'Costa, Katherine M McGrann, Donald W Hughes, Gerard D Wright, None, Sampling the antibiotic resistome. Science. ,vol. 311, pp. 374- 377 ,(2006) , 10.1126/SCIENCE.1120800
Krzysztof Sieradzki, Richard B. Roberts, Stuart W. Haber, Alexander Tomasz, The Development of Vancomycin Resistance in a Patient with Methicillin-Resistant Staphylococcus aureus Infection The New England Journal of Medicine. ,vol. 340, pp. 517- 523 ,(1999) , 10.1056/NEJM199902183400704