Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

摘要: Abstract The serotonin 1D (5-HT1D) receptor is a pharmacologically defined binding site and functional site. Observed variations in the properties of 5-HT1D receptors different tissues have led to speculation that multiple proteins with slightly may exist. We report here cloning, deduced amino acid sequences, pharmacological properties, second-messenger coupling pair human genes, which we designated alpha beta due their strong similarities sequence, coupling. Both genes are free introns coding regions, expressed cerebral cortex, can couple inhibition adenylate cyclase activity. The these two very similar, match closely human, bovine, guinea pig sites. exhibit high-affinity sumatriptan, new anti-migraine medication, thus candidates for action this drug.