Interactions of Carbon Nanotubes and Carbon Nanohorns with a Model Membrane Layer and Lung Surfactant In Vitro

摘要: A broader use of carbon nanomaterials increases the risk their inhalation as aerosol dispersed in air. Inhaled nanometer-sized particles are known to penetrate pulmonary region where they interact with lung surfactant first barrier meet and eventually surface cellular layer. This study presents results experimental studies physicochemical interactions between several types (nanotubes nanohorns various size properties) lipid layers two qualitatively different systems: Langmuir trough pulsated drop tensiometer, both providing complementary possibilities interfacial properties lipid-rich Quantified alterations mechanical if films (equilibrium compressibility, dynamic elasticity, viscosity) indicate that nanocarbons wettability may induce concentration-dependent frustration biological membranes vivo. The observed effects discussed not only relation health from nanoparticle but also potential medical applications engineered nanomaterials.