Reshaping a Human Antibody to Inhibit the Interleukin 6-dependent Tumor Cell Growth
作者： Mary M. Bendig , Koh Sato , Tadamitsu Kishimoto , Yoshiyuki Ohsugi , Yasuo Koishihara
DOI:
关键词: Virology 、 Immunotherapy 、 Immunoglobulin light chain 、 Cytokine 、 Antibody 、 Cell growth 、 Growth inhibition 、 Cancer research 、 Interleukin 6 、 Monoclonal antibody 、 Biology
摘要: The mouse PM-1 monoclonal antibody binds to the human interleukin 6 receptor, inhibits IL-6 functions, and shows strong antitumor cell activity against multiple myeloma cells. In order be effective as a therapeutic agent administered patients in repeated doses, reshaped antibodies consisting of REI-based light chain NEW-based heavy variable regions were designed constructed with assistance structural model regions. best is equivalent or chimeric terms antigen binding growth inhibition Only few minor changes framework required recreate antigen-binding site within antibody. antibody, therefore, could efficacious patients.
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