Antibacterial action of lipid nanocapsules containing fatty acids or monoglycerides as co-surfactants.

摘要: Lipid nanocapsules (LNCs) are a new generation of biomimetic nanocarriers obtained via phase inversion temperature method and have an oily core medium-chain triglycerides that is surrounded by shelf containing lipophilic surfactant (lecithin) hydrophilic macrogol 15-hydroxystearate. The aim the present study was to produce LNCs with antibacterial activity replacing lecithin other surface active compounds, namely fatty acids their 1-monoglycerides, which known antimicrobial properties. Fatty monoglycerides were found affect properties LNCs, such as particle size zeta potential. Incorporation co-surfactant decreased significantly (p⩽0.0039). Furthermore, incorporation either or at least 10 carbon atoms yielded potential more negative than composed solely 15 hydroxystearate (p⩽0.0310). Moreover, they capable decreasing temperature. LCNs against Gram-positive S. aureus, including methicillin-resistant strain, increased increases in length hydrocarbon tail. Monoglyceride-LNCs be corresponding acids. opposite behaviour observed for Gram-negative bacteria, whereby only caproic acid- caprylic acid-LNCs these organisms. monoglyceride-LNCs bactericidal, killed time-dependent manner. concentration-dependent A haemolysis assay performed obtain preliminary information on safety tested LNCs. In case acid-LNCs, concentrations bacterial growth inhibited similar haemolytic concentrations. However, showed action much lower those observed. conclusion, promising candidates carriers encapsulation agents, particularly aureus.