The role of prostacyclin in lung cancer

摘要: Prostanoids are bioactive lipids that interact with 7-membrane-spanning G-protein–coupled receptors on target cells to impart their biologic effects. 1 They include prostaglandins, prostacyclin, and thromboxane. widely distributed; mediate several diverse effects like platelet aggregation smooth-muscle contraction; known be involved in allergies, acquired immunity, cancer metastasis. 2 have also been associated breast endometrial promotion, the inhibition of melanoma. The role prostanoids development lung disease has poorly understood. In particular, prostacyclin possesses significant anti-inflammatory antimetastatic properties is main product cyclooxygenase-2 activity lung. fact, balance various members family, specifically prosoglandins PGE (PGI ), seems play an increasingly important cancer. Gaining a better understanding pathways critical future molecular-based pharmaceutical treatments disease.