Human papillomavirus-associated diseases in HIV-infected men who have sex with men.

摘要: Human papillomavirus (HPV) infections belong to themostcommonsexuallytransmittedinfectionsworldwide.HighHPVprevalencehasbeenreportedespeciallyintheyoung and sexually active population. In a recent studyonimmunocompetentheterosexualmen,overallanogen-italHPVinfectionshavebeenobservedin65.4%andanalHPV infection was present in 24.8% of these patients[1,2]. The vast majority HPV immuno-competent individuals is transient, the amount ofpersistent rather low. This contrast toimmunosuppressed individuals, for example, transplantrecipientsor patients with HIVinfection, exhibitinghighrates persistent infection. Consequently, theseindividuals have high risk HPV-associated malig-nant disease. Among HIV-positive patients, men whohave sex (MSM) are at highest analcanceranditspotentialprecursorlesion,analintraepithe-lial neoplasia(AIN)[3].Within thelast decade, sufficientdatawerepublishedtoconcludethatAINandanalcancercontinuously increase MSM despitethe use highly antiretroviral therapy (HAART).In contrast, only limited data currently availableon diseases other body sites ofHIV-positive MSM, penis or oral cavity.