Variations of Lipoprotein(a) Levels in the Metabolic Syndrome: A Report from the Maracaibo City Metabolic Syndrome Prevalence Study

作者: Valmore Bermúdez , Joselyn Rojas , Juan Salazar , Luis Bello , Roberto Áñez

DOI: 10.1155/2013/416451

关键词: Univariate analysisCholesterolCross-sectional studyEndocrinologyImpaired fasting glucoseLogistic regressionRisk factorMetabolic syndromePhysiologyMedicineInternal medicineLipoprotein(a)

摘要: Background. Lipoprotein(a) [Lp(a)] is a known risk factor for cardiovascular disease, yet its influence on metabolic syndrome (MS) still controversial. The purpose of this study was to assess the impact generated by diagnosis in serum Lp(a) concentrations. Materials and Methods. A total 1807 subjects both genders (55.3% women 44.7% men) belonging Maracaibo City Metabolic Syndrome Prevalence Study were evaluated. Results expressed as Mean ± SD, determining differences through Student’s t-test One-Way ANOVA test. Multiple logistic regression models utilized analyzing factors associated with elevated levels MS. Total cholesterol LDL-C corrected according Lp(a)-Cholesterol when necessary. Results. No found values between genders; . association MS classification statistically significant (; ), greater diagnosis. In univariate analysis, each separate diagnostic criteria showed higher concentrations, except hyperglycemia. Conclusions. exhibit important variations regarding components. Impaired fasting glucose appeared protecting against whereas hs-CRP suggests potential pro-inflammatory role.

参考文章(64)
JF Muñoz-Torrero, Dolores Rivas, Rodrigo Alonso, Leandro Crespo, Alberto Costo, Montana Roman, Carlos Martin, Jose Zamorano, None, Influence of lipoprotein (a) on inflammatory biomarkers in metabolic syndrome. Southern Medical Journal. ,vol. 105, pp. 339- 343 ,(2012) , 10.1097/SMJ.0B013E31825B5FB2
J Thillet, C Doucet, J Chapman, B Herbeth, D Cohen, L Faure-Delanef, Elevated lipoprotein(a) levels and small apo(a) isoforms are compatible with longevity: evidence from a large population of French centenarians. Atherosclerosis. ,vol. 136, pp. 389- 394 ,(1998) , 10.1016/S0021-9150(97)00217-7
R Siekmeier, H Scharnagl, GM Kostner, T Grammer, T Stojakovic, W März, Variation of Lp(a) Plasma Concentrations in Health and Disease The Open Clinical Chemistry Journal. ,vol. 3, pp. 72- 89 ,(2010) , 10.2174/1874241601003010072
Branislav Vohnout, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, The Relationship between Dyslipidemia and Inflammation Wiley-Blackwell. pp. 202- 210 ,(2011) , 10.1002/9781444318456.CH26
Juan Salazar, Yaquelin Torres, Tibisay Rincón, Luis Bello, Roberto Añez, Alexandra Toledo, Maricarmen Chacín, Marjorie Villalobos, Freddy Pachano, María Montiel, Valmore Bermúdez, Miguel Ángel Aguirre, Rafael París Marcano, Manuel Velasco, Mayela Cabrera, Laura Mendoza, Mervin E Chávez, María S Martínez, Joselyn Rojas, Alejandra Nava, Diego Fuenmayor, Vanessa Apruzzese, None, Epidemiological behavior of high -sensitivity C-Reactive Protein (hs-CRP) in adult individuals in the Maracaibo city, Venezuela Revista Latinoamericana De Hipertension. ,vol. 8, pp. 16- 24 ,(2013)
Daniela Gotera, Hamid Seyfi, Anilsa Amell, Edgardo Mengual, Valmore Bermúdez, Mariluz Núñez, Xavier Guerra, Mayerlim Medina, Judith Faría, Sergia Linares, Daniel Aparicio, Edward Rojas, Clímaco Cano, Aida Souki, Luis Sorell, Manuel Velasco, Niveles inusualmente elevados de Lipoproteína(a) en poblaciones Afro-Americanas del sur del Lago de Maracaibo Revista Latinoamericana De Hipertension. ,vol. 3, pp. 195- 200 ,(2008)
D. M. Neele, E. C. M. de Wit, H. M. G. Princen, Insulin suppresses apolipoprotein(a) synthesis by primary cultures of cynomolgus monkey hepatocytes. Diabetologia. ,vol. 42, pp. 41- 44 ,(1999) , 10.1007/S001250051110
Alp Aydinalp, Bülent Ozin, Aylin Yildirir, Serpil Eroğlu, Hüseyin Bozbaş, Ilyas Atar, Taner Ulus, Mehmet E Korkmaz, Haldun Müderrisoğlu, Bahar Pirat, Increased lipoprotein(a) in metabolic syndrome: is it a contributing factor to premature atherosclerosis? Anadolu Kardiyoloji Dergisi-the Anatolian Journal of Cardiology. ,vol. 8, pp. 111- 115 ,(2008)
K H Adeli, M Binesh Marvasti, Pharmacological management of metabolic syndrome and its lipid complications. DARU. ,vol. 18, pp. 146- 154 ,(2010)
Syed Fayaz Ahmad Shah, Syed Shahid Habib, Abdul Khaliq Naveed, Muhammad Aslam, Lipoprotein (a) is associated with basal insulin levels in patients with type 2 Diabetes Mellitus. Arquivos Brasileiros De Cardiologia. ,vol. 93, pp. 28- 33 ,(2009) , 10.1590/S0066-782X2009000700006