Aqueous, protein-driven synthesis of transition metal-doped ZnS immuno-quantum dots.

摘要: The intentional introduction of transition metal impurities in semiconductor nanocrystals is an attractive approach for tuning quantum dot emission over a wide range wavelengths. However, the development effective doping strategies can be challenging, especially if one simultaneously requires low-toxicity crystalline core, functional protein shell, and “green”, single-step synthesis process. Here, we describe simple environmentally friendly route biofabrication Cu-doped (blue-green) or Mn-doped (yellow-orange) ZnS surrounded by antibody-binding shell. ZnS:Mn hybrid particles obtained with this method exhibit 60% enhancement maximum photoluminescence intensity relative to undoped have hydrodynamic diameter inferior 10 nm. They stored months at 4 °C, are stable physiological pH salt concentrations, decorated variable amounts antibodies direct mixing, hold promise biose...