Metabolic Dyslipidemia and Risk of Coronary Heart Disease in 28,318 Adults With Diabetes Mellitus and Low-Density Lipoprotein Cholesterol <100 mg/dl

摘要: The risk of future coronary heart disease (CHD) in subjects with diabetes and "metabolic dyslipidemia" (high triglyceride [TGs] low high-density cholesterol levels) remains a matter concern. Little is known regarding the CHD for this phenotype low-density lipoprotein (LDL-C) levels <100 mg/dl. We analyzed cohort 28,318 members (aged 30 to 90 years) Kaiser Permanente Northern California during 2002 2011 (192,356 person-years [p-y] follow-up), LDL-C mg/dl without CHD. compared incidence hazard ratios (HRs) events groups using Cox models: normal (HDL) TG (reference; n = 7,278, 25.7%); HDL high (≥ 150 mg/dl; 4,484,15.8%); (≤ 50 women ≤ 40 men) (n 4,048, 14.3%); (metabolic dyslipidemia; 12,508, 44%). Patients metabolic dyslipidemia had highest age-adjusted events/1,000 p-y (12.7/1,000 19.0/1,000 men, respectively). After multivariate adjustment age, gender, ethnicity, hypertension, smoking, statin use, duration diabetes, hemoglobin A1c, we observed an increased (HR 1.35, 95% confidence interval 1.14 1.60) men 1.62, 1.43 1.83) those TG. Even mg/dl, presence adults associated In conclusion, effective prevention strategies are needed dyslipidemia.