Prophylaxis versus treatment of acetylstrophanthidin intoxication

作者: Howard J Zeft , Robert E Whalen , James J Morris , Nicholas J Rummo , Henry D McIntosh

DOI: 10.1016/0002-8703(69)90356-1

关键词: TachycardiaBlockadePropranololAdrenergic receptorAnesthesiaMedicineToxicityVentricular tachycardiaMortality rateDigitalisCardiology and Cardiovascular Medicine

摘要: Abstract Treatment and pretreatment of acetylstrophanthidin-induced ventricular tachycardia was studied in awake pigs. The pharmacologic agents employed were diphenylhydantoin 2 beta-adrenergic blocking agents, MJ 1999 propranolol. These when administered intravenously at the onset arrhythmia significantly shortened duration tachycardia. Pretreatment with doses ranging from 5 to 30 mg. per kilogram failed increase acetylstrophanthidin intoxicating doses. propranolol, likewise, showed no prophylactic effect on intoxication. Animals pretreated had a shorter tachycardia, whereas animals propranolol exhibited high mortality rate. This increased rate possibly resulted more profound blockade beta receptors or severe myocardial depression. findings indicate that drugs, which are effective acute therapy digitalis arrhythmias, do not protect against toxicity 1999, previously considered specific for catecholamine-induced found antagonize by decreasing may be relevant clinical situations where digitalization is undertaken patients receiving certain agents.

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