Inhibition of iron transport across human intestinal epithelial cells by hepcidin

摘要: We investigated the effects of iron regulatory peptide hepcidin on transport by human intestinal epithelia[ Caco-2 cell line. cells were exposed to for 24 hours prior measurement both and transporter protein mRNA expression. Incubation with significantly decreased apical uptake cells. This was accompanied a decrease in expression iron-response element containing variant divalent metal (DMT1 [+IRE]). In contrast, efflux iron-regulated gene1 (IREG1) unaffected hepcidin. Hepcidin interacts directly model epithelium. The primary effect this is modulate membrane machinery, thereby controlling amount absorbed from diet. (C) 2004 American Society Hematology.