Regulatory T cells: first steps of clinical application in solid organ transplantation.

摘要: Solid organ transplantation is the treatment of choice for patients with end-stage failure. To prevent rejection transplanted continuous immunosuppressive medication needed. Immunosuppression may be harmful to transplant recipient, increasing risk cancer, infections and cardiovascular disease. improve patient survival, there a need an immune-modulatory regimen that not only potent in preventing organ, but has less side effects compared current regimens. Increasingly, research focusses on regulatory T cell (Treg) therapy achieve this aim, which Treg are used as strategy allow reduction immunosuppression. Currently, first clinical trials underway investigating safety feasibility renal transplantation. This review gives overview rationale using transplantation, previous experience humans, expected safety, potential efficacy cost-effectiveness solid