Quantified Visual Scoring of Metastatic Melanoma Patient Treatment Response Using Computed Tomography: Improving on the Current Standard

摘要: To assess whether quantitative visual scoring (QVS) is a better early predictor of progression-free survival (PFS) in patients on chemotherapy for metastatic melanoma using CT than the currently used Response Evaluation Criteria Solid Tumors (RECIST) standard. Retrospective evaluation 65 consecutive with treatment who had baseline and follow-up after two cycles therapy. QVS was to code imaging findings radiology reports considering size change, brain metastases, new lesions, mixed lesion response, number organ systems involved. RECIST 1.1 criteria placed progressive disease, stable or partial response groups. Multiple regression analysis correlate various independent variables PFS. The Cox hazard proportions ratio, median survival, Kaplan–Meier curves different prognostic groups were calculated. change found more sensitive detecting deteriorating (57.1% versus 37.5%) improving (23.8% 10.7%), correlated PFS (1.8 1.7 months), (5.6 4.0 month), (8.3 5.5 months) categories predictive (Cox proportion ratio 3.070 1.860) categorization. demonstrated most closely among assessed (r = 0.519, p < 0.0001). this study superior standard categorization terms discriminating treated likely have longer