Tumor targeting HPMA-porphyrin-99mTc copolymer molecular imaging agent
作者： Long Yuan , Yabing Ma , Jianchao Yuan
DOI: 10.1080/09205063.2014.970064
关键词: In vitro 、 Endocytosis 、 Methacrylamide 、 Copolymer 、 Tumor targeting 、 Molecular imaging 、 Biochemistry 、 Materials science 、 Biodistribution 、 Porphyrin
摘要: Porphyrins typically show preferential uptake and retention by tumor tissues via receptor-mediated endocytosis of low-density lipoproteins. To investigate the relative importance active passive targeting strategies, synthesis, characterization, in vitro uptake, vivo biodistribution specific porphyrin HPMA [HPMA: N-(2-hydroxypropyl)methacrylamide] copolymer tracer poly(HPMA)-porphyrin-DTPA-99mTc (DTPA: diethylenetriaminepentaacetic acid), nonspecific poly(HPMA)-DTPA-99mTc, nontargeting DTPA-99mTc are described this study. The results showed that cellular accumulation complex was found to be time-dependent. significantly higher than indicating binding. poly(HPMA)-DTPA-99mTc DTPA-99mTc, suggesting ...
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