Healthy supplements of silymarin and aqueous extract of Salvia miltiorrhiza on the pharmacokinetic interaction of lamivudine in rats

摘要: Abstract Silymarin and Salvia miltiorrhiza are commonly used in various functional foods, daily herbal health supplements food for the treatment prevention of liver disease. The aim this study was to evaluate herbal–drug interactions silymarin aqueous extract S. miltiorrhiza (AESM) on pharmacokinetics lamivudine rat plasma as measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS). A rapid sensitive LC–MS/MS method developed validated according Food Drug Administration (FDA) guidelines. Experimental rats were divided into following four parallel groups: (1) (10 mg/kg, i.v.) alone a control group, (2) i.v.) + pretreated with (0.5 g/kg/day, p.o., 5 days), (3) AESM (1.0 g/kg/day, (4) days) + AESM days). pharmacokinetic results demonstrate that significantly increased half-life (t 1/2 ), area-under concentration curve (AUC), mean residence time (MRT), while clearance (CL) decreased. Thus, provides preclinical information regarding between supplements.