Hyaluronan, a beneficial glycosaminoglycan that may affect the phenotype of cardiac hypertrophy – a hypothesis

摘要: Myocardial hypertrophy contribute to ventricular diastolic dysfunction and can lead heart failure, arrhythmia even sudden death. It have been shown that during development of the concentration glycosaminoglycan hyaluronan increases. The increased correlates gene expression fetal extracellular matrix genes is associated with cardiac remodeling. Moreover it has high molecular weight depolarize membrane potential cells. increase in could hypothetically affect resting cardiomyocytes thus conduction through heart. Hypothesis. role as a molecule adapting when growing potentially develop be harmful cardiomyocyte hence risk arrhythmia.