No Improvement of Posttraumatic Stress Disorder Symptoms With Guanfacine Treatment
作者： Thomas C Neylan , Frank B Schoenfeld , Thomas J Metzler , Jerome A Yesavage , Maryann Lenoci
DOI: 10.1176/APPI.AJP.163.12.2186
关键词: Posttraumatic stress 、 Physical therapy 、 Anesthesia 、 Alpha-2 adrenergic receptor 、 Pharmacotherapy 、 Placebo 、 Comorbidity 、 Psychology 、 Guanfacine 、 Randomized controlled trial 、 Anxiety disorder
摘要: Objective: The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD). Method: Veterans with chronic PTSD who were medication-free or receiving stable pharmacotherapy randomly assigned to (N=29) (N=34). Results: Guanfacine had no effect on symptoms, subjective sleep quality, general mood disturbances. was associated a number side effects. Conclusions: These results do not support the use alpha 2 agonists in veterans PTSD.
researchgate.net 
sci-hub.st 参考文章(3)
Steven M Southwick, John H Krystal, C Andrew Morgan, David Johnson, Linda M Nagy, Andreas Nicolaou, George R Heninger, Dennis S Charney, None, Abnormal Noradrenergic Function in Posttraumatic Stress Disorder Archives of General Psychiatry. ,vol. 50, pp. 266- 274 ,(1993) , 10.1001/ARCHPSYC.1993.01820160036003
Murray A. Raskind, Charles Thompson, Eric C. Petrie, Dorcas J. Dobie, Rebekah J. Rein, David J. Hoff, Miles E. McFall, Elaine R. Peskind, Prazosin Reduces Nightmares in Combat Veterans With Posttraumatic Stress Disorder The Journal of Clinical Psychiatry. ,vol. 63, pp. 565- 568 ,(2002) , 10.4088/JCP.V63N0705
Fred D. Gusman, Frank W. Weathers, Terence M. Keane, Dudley David Blake, Dennis S. Charney, Linda M. Nagy, Danny G. Kaloupek, The development of a Clinician-Administered PTSD Scale. Journal of Traumatic Stress. ,vol. 8, pp. 75- 90 ,(1995) , 10.1007/BF02105408