Biotransformation of dehydroepiandrosterone (DHEA) by environmental strains of filamentous fungi
作者： Ewa Kozłowska , Monika Urbaniak , Anna Kancelista , Monika Dymarska , Edyta Kostrzewa-Susłow
DOI: 10.1039/C7RA04608A
关键词: Dehydroepiandrosterone 、 Biotransformation 、 Chemistry 、 Aspergillus versicolor 、 Penicillium 、 Stereochemistry 、 Mucor hiemalis 、 Steroid 、 Biochemistry 、 Hydroxylation 、 Strain (chemistry)
摘要: Microbial transformations of steroids are an important method obtaining new steroid derivatives potential pharmaceutical activity, which follows the principles green chemistry. We studied ability selected filamentous fungus species to transform dehydroepiandrosterone (DHEA) and interesting DHEA were obtained. Twenty-five strains fungi isolated from soil air in Wroclaw they used as biocatalysts. Strains genus Penicillium transformed substrate into products Baeyer–Villiger lactonization D ring. Biotransformation by Fusarium acuminatum KCh S1 strain led a stereoselective hydroxylation at 7α (the product was obtained with 97% conversion). Androst-5-ene-3β,7α,17α-triol, compound high anticancer activity towards glioblastoma lymphoma cell lines 65% yield culture Mucor hiemalis W2 strain. In Aspergillus versicolor TJ1 strain, androst-1,4-diene-3,17-dione (ADD) yield.
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