Effect of bromine and chlorine positioning in the induction of renal and testicular toxicity by halogenated propanes.

摘要: A series of halogenated propanes were studied for renal and testicular necrogenic effects in the rat correlated to their ability induce vivo DNA damage vitro damage. 1,2-Dibromo-3-chloropropane (DBCP) 1,2,3-tribromopropane most potent causing organ both kidney testes. Extensive necrosis was evident at 85 mumol/kg 170 testis. The dibromomonochlorinated analogue 1,3-dibromo-2-chloropropane less toxic than DBCP 1,2,3-tribromopropane, but induced more dichloromonobrominated analogues 1-bromo-2,3-dichloropropane 1,3-dichloro-2-bromopropane. Dihalogenated even necrogenic. These observed differences potency between could not be explained by relative tissue concentrations. well with However, occurred lower doses a shorter period exposure necrosis. This indicates that might an initial event development general. Further, isolated cells vitro, showing toxicity due situ activation. numbers, positions, types halogen substituents appear important determinants effects.(ABSTRACT TRUNCATED AT 250 WORDS)