A Systematic Review of the effect and safety of Ginger in the treatment of pregnancy- associated nausea and vomiting

摘要: Background: Nausea and vomiting during pregnancy (NVP) is a common medical condition. Due to possible harmful side-effects that conventional medicine may pose the fetus, many mothers choose not use it, are left helpless against NVP. There need for alternative treatment relieve NVP symptoms. Objectives: This systematic review (SR) investigated current evidence regarding ginger of The primary objective was assess effectiveness in treating secondary safety pregnancy, by identifying adverse events or side-effects. Search strategy: Electronic search bibliographic databases (1966-February 2011). Selection criteria: Randomized controlled trials (RCTs) efficacy any route, as pregnant women regardless their age stage pregnancy. Data collection analysis: principal investigator independent reviewer individually identified relevant studies, extracted data assessed trial quality. analysis performed using RevMan5 software. Differences at level p<0.05 were considered be statistically significant. Results: Eleven RCTs involving 1176 included. quality low, hence high risk bias imprecision results. Ginger significantly improved symptoms nausea when compared placebo, comparing results this SR past SRs, taking into account meta-analysis on two relatively large included studies (mean difference (MD) 1.20, 95% confidence interval (CI) 0.56-1.84, p=0.0002, I 2 =0%). However, another smaller indicated no significant improvement nausea. did improve vitamin B6 (MD 0.34, CI -1.522.20, p=0.7, =91%). Similarly, reduce number episodes NVP, although there trend Stellenbosch University http://scholar.sun.ac.za