Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?

摘要: BACKGROUND Distant metastases are found in approximately 35% of patients with gastric cancer at their first clinical observation, and these, 4%-14% involves the liver. Unfortunately, only 0.4%-2.3% metastatic eligible for radical surgery. Although surgical resection is still debated, there have been changes recent years, although several issues remain to be defined that must taken into account before surgery proposed. AIM To analyze clinicopathological factors related primary tumor impact survival liver cancer. METHODS We performed a systematic review literature from 2000 2018 according Preferred Reporting Items Systematic Reviews Meta-Analyses statement. The study protocol was based on identifying studies clearly purpose, eligibility criteria, methodological analysis, patient outcome. RESULTS selected 47 pertaining purpose review, which involved total 2304 patients. Median 7-52.3 mo, median disease-free 4.7-18 mo. 1-, 2-, 3-, 5-year overall (OS) 33%-90.1%, 10%-60%, 6%-70.4%, 0%-40.1%, respectively. Only five papers reported 10-year OS, 5.5%-31.5%. general recurrence rate between 55.5% 96%, hepatic 15% 94%. CONCLUSION Serous infiltration lymph node involvement indicate an unfavorable prognosis, while presence single metastasis or ≤ 3 associated size < 5 cm may considered data do not contraindicate resection.