HOXB2 as a Novel Prognostic Indicator for Stage I Lung Adenocarcinomas
作者： Kentaro Inamura , Yuki Togashi , Michiyo Okui , Hironori Ninomiya , Miyako Hiramatsu
DOI: 10.1097/JTO.0B013E3181461987
关键词: Normal tissue 、 Cancer 、 Disease 、 Pathologic stage 、 Normal lung 、 Medicine 、 Internal medicine 、 Lung 、 Adenocarcinoma 、 Polymerase chain reaction analysis 、 Oncology
摘要: Background Outcomes of patients with lung adenocarcinomas can be predicted to some extent from the pathologic stage (p-stage). Although all attempts are made fully remove cancer lesions, still a number p-stage I without metastatic disease at time surgery develop recurrences and die cancer. It is thus very important identify who risk recurrence. Methods Previously, using microdissected samples, we identified metastasis-related genes. Using real-time reverse-transcriptase polymerase chain reaction analysis, investigated transcriptional levels top genes 96 independent test adenocarcinoma samples their correlations prognosis. Results Conclusions We document evidence that HOXB2 up-regulation have worse prognosis than those down-regulation ( p = 0.0065), whereas status has no prognostic significance for II–IV patients. Comparing tumors corresponding normal tissue, confirmed up-regulated lesions much higher expression tissue. Confirmation larger needed, further research clarify molecular functions HOXB2.
jto.org
sci-hub.se 参考文章(26)
Heiko A. Golpon, Mark W. Geraci, Mark D. Moore, Heidi L. Miller, Gary J. Miller, Rubin M. Tuder, Norbert F. Voelkel, HOX Genes in Human Lung The American Journal of Pathology. ,vol. 158, pp. 955- 966 ,(2001) , 10.1016/S0002-9440(10)64042-4
C. Cillo, P. Barba, G. Freschi, G. Bucciarelli, M. C. Magli, E. Boncinelli, HOX gene expression in normal and neoplastic human kidney International Journal of Cancer. ,vol. 51, pp. 892- 897 ,(1992) , 10.1002/IJC.2910510610
M Hatano, C. Roberts, M Minden, W. Crist, S. Korsmeyer, Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science. ,vol. 253, pp. 79- 82 ,(1991) , 10.1126/SCIENCE.1676542
Clifton F. Mountain, Revisions in the International System for Staging Lung Cancer Chest. ,vol. 111, pp. 1710- 1717 ,(1997) , 10.1378/CHEST.111.6.1710
F. Apiou, D. Flagiello, C. Cillo, B. Malfoy, M.-F. Poupon, B. Dutrillaux, Fine mapping of human HOX gene clusters Cytogenetic and Genome Research. ,vol. 73, pp. 114- 115 ,(1996) , 10.1159/000134320
Kentaro Inamura, Takashi Shimoji, Hironori Ninomiya, Miyako Hiramatsu, Michiyo Okui, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Tetsuo Noda, Masashi Fukayama, Yuichi Ishikawa, A metastatic signature in entire lung adenocarcinomas irrespective of morphological heterogeneity. Human Pathology. ,vol. 38, pp. 702- 709 ,(2007) , 10.1016/J.HUMPATH.2006.11.019
Thomas A. D'Amico, MD, Marga Massey, MD, James E. Herndon II, PhD, Mary-Beth Moore, David H. Harpole, A biologic risk model for stage I lung cancer: Immunohistochemical analysis of 408 patients with the use of ten molecular markers The Journal of Thoracic and Cardiovascular Surgery. ,vol. 117, pp. 736- 743 ,(1999) , 10.1016/S0022-5223(99)70294-1
Marie Wislez, David G. Beer, Ignacio Wistuba, Jacques Cadranel, Nagahiro Saijo, Bruce E. Johnson, Molecular Biology, Genomics, and Proteomics in Bronchioloalveolar Carcinoma Journal of Thoracic Oncology. ,vol. 1, pp. S8- S12 ,(2006) , 10.1016/S1556-0864(15)30003-4
M. Cantile, G. Pettinato, A. Procino, I. Feliciello, L. Cindolo, C. Cillo, In vivo expression of the whole HOX gene network in human breast cancer. European Journal of Cancer. ,vol. 39, pp. 257- 264 ,(2003) , 10.1016/S0959-8049(02)00599-3
Davendra Segara, Andrew V. Biankin, James G. Kench, Catherine C. Langusch, Amanda C. Dawson, David A. Skalicky, David C. Gotley, Maxwell J. Coleman, Robert L. Sutherland, Susan M. Henshall, Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia. Clinical Cancer Research. ,vol. 11, pp. 3587- 3596 ,(2005) , 10.1158/1078-0432.CCR-04-1813