Rethinking the multiple roles of B cells in organ transplantation

摘要: PURPOSE OF REVIEW To discuss the B-cell diverse functions in organ transplantation, highlighting emerging debate on role of regulatory B cells (Bregs). We underscore need to re-examine and integrate data functional activities, aiming discriminate their (REG) inflammatory (INFLAMMA) translate this knowledge for development novel immunomodulatory therapeutic strategies rethink current ones. RECENT FINDINGS Data from both experimental models clinical trials point that various phenotypes have immunoregulatory activity play an important controlling graft inflammation. state operational tolerance, kidney suggest relevance preserving a healthy compartment - numbers Breg capacity activate CD40/STAT3 signalling pathway achieving maintaining homeostasis. Moreover, autoantibodies also comprise transplant immunobiology it seems not all alloantibodies are deleterious. SUMMARY The cells, can no longer be taken as mere generators plasma which produce deleterious graft. seem complex network with Bregs possibly antibodies. discrimination REG/INFLAMMA roles needs considered setting.