Regulation of bile acid and cholesterol metabolism by PPARs.

摘要: Bile acids are amphipathic molecules synthesized from cholesterol in the liver. acid synthesis is a major pathway for hepatic catabolism. generates bile flow which important biliary secretion of free cholesterol, endogenous metabolites, and xenobiotics. biological detergents that facilitate intestinal absorption lipids fat-soluble vitamins. Recent studies suggest metabolic regulators lipid, glucose, energy homeostasis. Agonists peroxisome proliferator-activated receptors (PPARα, PPARγ, PPARδ) regulate lipoprotein metabolism, fatty oxidation, glucose homeostasis inflammation, therefore used as anti-diabetic drugs treatment dyslipidemia insulin insistence. have shown activation PPARα alters synthesis, conjugation, transport, also reverse transport. This review will focus on roles PPARs regulation pathways homeostasis, therapeutic implications using PPAR agonists syndrome.