Doxycycline poly e-caprolactone nanofibers in patients with chronic periodontitis - a clinical evaluation.
作者： TP Chaturvedi , Ruchi Srivastava , AK Srivastava , Varun Gupta , Pushpendra Kumar Verma
DOI: 10.7860/JCDR/2013/5858.3519
关键词: Drug 、 Medicine 、 Internal medicine 、 Nanofiber 、 Chronic periodontitis 、 Clinical evaluation 、 In patient 、 Doxycycline 、 Caprolactone 、 Scaling and root planing 、 Dentistry 、 Gastroenterology
摘要: Aim: To develop a low-dose controlled-release delivery system for the treatment of periodontal infections. A new sustained release drug Poly e-caprolactone (PCL) nanofibers containing doxycycline (DOX) was successfully electrospun and evaluated clinically diseases. The retentive nanofibres were shown to provide controlled drug. Material Methods: Nanofibers prepared with DOX in PCL by electrospinning technique. drug-coated provided effect up period 11 days (264 h) followed first order release. Forty sites 7 patients (4 females 3 males) chronic periodontitis (5-8mm probing depth) allocated 2 experimental groups, Group A-SRP (Scaling Root Planing) + B –SRP Planing) alone (control group). All these depth (PD), plaque index (PI) gingival (GI). Results: Both groups found be efficacious disease as demonstrated improvement PD, PI GI. Conclusion: Combination SRP + (Group A) resulted added benefits compared control group.
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