Fluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis.
作者： Jaimeen Devraj Majmudar , Christopher W. am Ende , Kevin Ogilvie , Timothy L. Foley , Subham Mahapatra
关键词: Reagent 、 On demand 、 Reactivity (chemistry) 、 Combinatorial chemistry 、 Activity-based proteomics 、 Chemistry
摘要: Herein, we report a general and simplified synthesis of fluorophosphonates directly from p-nitrophenylphosphonates. This FP on-demand reaction is mediated by commercially available polymer-supported fluoride reagent that produces variety (25 examples) in high yields while only requiring filtration for pure fluorophosphonate isolation. protocol facilitates the rapid profiling serine hydrolases with diverse novel sets activated phosphonates differential proteome reactivity. Moreover, slight modification procedure into reaction-to-assay format has enabled additional screening efficiency.
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