Clinical utility of 4D FDG-PET/CT scans in radiation treatment planning

摘要: Purpose The potential role of four-dimensional (4D) positron emission tomography (PET)/computed (CT) in radiation treatment planning, relative to standard three-dimensional (3D) PET/CT, was examined. Methods and Materials Ten patients with non–small-cell lung cancer had sequential 3D 4D [ 18 F]fluorodeoxyglucose PET/CT scans the position prior therapy. gross tumor volume involved lymph nodes were contoured on PET scan by use three different techniques: manual contouring an experienced oncologist using a predetermined protocol; technique constant threshold standardized uptake value (SUV) greater than 2.5; automatic segmentation technique. For each technique, defined (VOL3D) (VOL4D) combining five breathing phases individually. range motion location lesion also recorded, their influence differences observed between VOL3D VOL4D investigated. Results We identified analyzed 22 distinct lesions, including 9 primary tumors 13 mediastinal nodes. Mean larger mean all techniques, difference statistically significant ( p Conclusions In comparison PET, may better define full physiologic extent moving improve planning for tumors. addition, reduction blurring from free-breathing images reveal additional information regarding regional disease.