Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase.
作者： Daret K. St. Clair , X. Steven Wan , Terry D. Oberley , Kenneth E. Muse , William H. St. Clair
关键词: Transfection 、 Cell biology 、 Superoxide dismutase 、 Oxidative stress 、 Cell culture 、 Biochemistry 、 Neoplastic transformation 、 Malignant transformation 、 Carcinogenesis 、 Biology 、 Mitochondrion
摘要: Manganese superoxide dismutase (MnSOD) scavenges toxic radicals produced in the mitochondria. Transfection of human MnSOD gene into mouse C3H 10T1/2 cells resulted production active MnSOD, which was properly transported Overexpression protected from radiation-, but not chemically-induced neoplastic transformation. This finding demonstrates that oxidative stress occurs mitochondria plays an important role development
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