The point mutation analysis of Cyp2C9*2 (Arg144Cys C>T), Cyp2C9*3 (Ile359Leu A>C) and VKORC1 (1639G>A) in women with cervical cancer related to HPV: A case-control study.

摘要: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide. HPV tumorigenesis genotypes are causative agents of cervical cancer and genital malignancies. The scientific literature has demonstrated that life style, environmental, epigenetic accompanied with HR-HPV are potential risk factors for cervical progression. frequencies Cyp2C9*2 , Cyp2C9*3 vitamin K epoxide reductase complex subunit 1 (VKORC1) as potential molecular biomarkers have been investigated on Iranian women malignancy related to genotypes. As a case-control study, mutations were appraised using polymerase chain reaction-restriction fragment length polymorphism procedure suffering from (60 cases), CC (46 40 subjects healthy control. outcomes  showed meaningful relationship between diagnosed population (AA vs. AC; OR, 7.15; 95% CI, 1.94-26.3; p = .003). It was also observed mutation in VKORC1 (+), did not follow Hardy-Weinberg equilibrium. Our findings aid understanding genetic distribution This can be useful predicting susceptibility for developing cancer. However, allelic discrimination biomarker requires further research.