Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults
作者： Zi-Hong He , Yang Hu , Yan-Chun Li , Da-Peng Bao , Jonatan R. Ruiz
DOI: 10.1007/S00421-010-1558-8
关键词: Endocrinology 、 Ejection fraction 、 Physical exercise 、 Genotype 、 Calcineurin 、 Biology 、 Polymorphism (computer science) 、 Stroke volume 、 Internal medicine 、 Phenotype 、 Endurance training
摘要: We studied the association of 55 polymorphisms in PPP3CA, PPP3CB, PPP3CC, PPP3R1 and PPP3R2 genes with both (1) pre-training levels (2) responsiveness to endurance training (18 weeks), echocardiographic variables. The latter were measured before after program at each following time points: (rest), during cycle-ergometry exercise. Subjects healthy young Chinese men Han origin [n = 102; mean (SD) age: 19 ± 1 years]. To assess genotype:phenotype associations pre-training, we used a one-factor (genotype) ANOVA for polymorphism. between polymorphism cardiac phenotypes, two-factor (genotype x training) repeated measures. All multiple comparisons corrected mass significance. For only found significant rs3763679 (PPP3CB) resting heart rate. As genotype trainability (i.e. × interaction effect): rs1879793, rs1075534, rs7430, rs2461483 rs10108011 (PPP3CC) output/stroke volume exercise; rs1407877 (PPP3R2) ejection fraction 50 W. findings suggest that calcineurin might be among numerous potential genetic variant candidates can help explaining human variations or phenotype traits.
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