The Role of Lipid Metabolism for Neural Stem Cell Regulation.

摘要: Neural stem/progenitor cells (NSPCs) give rise to billions of during development and are critical for proper brain formation. The finding that NSPCs persist throughout adulthood has challenged the view poor regenerative abilities raised hope stem cell-based therapies. For decades there been a strong movement towards understanding requirements their regulation, resulting in discovery many transcription factors signaling pathways can influence NSPC behavior neurogenesis. However, role metabolism regulation only gained attention recently. Lipid particular shown proliferation neurogenesis, offering exciting new possible mechanisms as lipids not building blocks membranes, but also act alternative energy sources entities. Here I review recent literature examining lipid