Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

摘要: Immunoregulatory T cells of (CD4+)CD25+ phenotype suppress cell function and protect rodents from organ-specific autoimmune disease. The human counterpart this subset expresses high levels CD25 its role in disorders is currently under intense investigation. In multiple sclerosis (MS), a chronic inflammatory disease the central nervous system (CNS), activation circulating self-reactive with specificity for myelin components considered to be an important initiating event. Here, we investigated whether MS associated altered ability (CD4+)CD25high regulatory (Treg) confer suppression myelin-specific immune responses. Whereas Treg frequencies were equally distributed blood cerebrospinal fluid patients did not differ compared healthy controls, suppressive potency patient-derived lymphocytes was impaired. Their inhibitory effect on antigen-specific proliferation induced by recombinant oligodendrocyte protein as well responses elicited polyclonal allogeneic stimuli significantly reduced individuals. persistent due responder resistance or survival Treg, suggesting that defective immunoregulation peripheral mediated promotes CNS autoimmunity MS.