Chapter 9 The neuropeptide concept

摘要: Publisher Summary Neuropeptides are endogenous substances present in nerve cells that involved nervous system function. synthesized large precursor proteins, and several formed the same such as adrenocorticotropic hormone (ACTH) β-endorphin proopiomelanocortin (POMC). A cascade of processes evolves peptidergic neurons to express genetic information into biologically active neuropeptides. These control quantities neuropeptides nature their biological activity, through size, form, derivatization end-product. In this way sets with different, opposite, more selective properties from precursor. Many peptides pituitary origin found gastrointestinal tract, heart, even amphibian skin brain. together Met- Leu-enkephalin, Substance P related tachykinins, neurotensin, releasing hormones release inhibiting hormones, vasopressin oxytocin, angiotensin II detected often co-localized classical transmitters cholecystokinin-like dopamine terminals nucleus accumbens which they released.