A score combining baseline neutrophilia and primary tumor SUV peak measured from FDG PET is associated with outcome in locally advanced cervical cancer

摘要: We investigated whether a score combining baseline neutrophilia and PET biomarker could predict outcome in patients with locally advanced cervical cancer (LACC). Patients homogeneously treated definitive chemoradiation plus image-guided adaptive brachytherapy (IGABT) between 2006 2013 were analyzed retrospectively. divided into two groups depending on the device used: training set (TS) validation (VS). Primary tumors semi-automatically delineated images, and 11 radiomics features calculated (LIFEx software). A radiomic index was selected using time-dependent area under curve (td-AUC) for 3-year local control (LC). defined neutrophil SUV grade (NSG = 0, 1 or 2) as number of risk factors among (i) (neutrophil count >7 G/L) (ii) high from index. The NSG prognostic value evaluated LC overall survival (OS). Data 108 analyzed. Estimated 72% TS (n = 69) 65% VS (n = 39). In TS, SUVpeak most LC-predictive (td-AUC = 0.75), independent (p = 0.119). Neutrophilia (HR = 2.6), high-risk (SUVpeak > 10, HR = 4.4) NSG = 2 (HR = 9.2) associated low probability TS. multivariate analysis, independently (HR = 7.5, p < 0.001) OS (HR = 5.8, p = 0.001) Results obtained (HR = 5.2 3.5 LC, p < 0.02) promising. This innovative scoring approach provides an factor to consider further clinical investigations.