Metabolism and epilepsy: Ketogenic diets as a homeostatic link.

摘要: Metabolic dysfunction can underlie seizure disorders, and metabolism-based treatments afford control promote homeostasis. This relationship between metabolism the risk of sporadic seizures was observed historically with clinical success a low-carbohydrate, high-fat, ketosis-inducing ketogenic diet - treatment that remains relevant today, one has been shown to be effective against medically refractory epilepsy. Mechanisms underlying are topic intense research efforts not only because proven in arresting treatment-resistant seizures, but also recent evidence suggests altering enables homeostatic state brain is less excitable, hence raises threshold for genesis. therapy normalize range abnormal physiological behavioral parameters may make central nervous system more resilient other insults or stresses. Because therapeutic ability such limited than drug dose "ceiling", investigations underway develop test analogous supplemental approaches. In addition, significant have made demonstrate broader applications metabolic promoting health preventing disease, including conditions where epileptic manifest comorbid fashion.