Distinct Functions of MEKK3 and MEKK4 in Heart Valve Morphogenesis
作者： Mark V. Stevens
DOI:
关键词: Heart valve morphogenesis 、 Signal transduction 、 Heart morphogenesis 、 ErbB 、 Epithelial–mesenchymal transition 、 Endocardial cushion formation 、 Pathology 、 Mitral valve prolapse 、 Biology 、 Extracellular matrix
摘要: 16 CHAPTER 1 – INTRODUCTION 18 1.1. HEART MORPHOGENESIS 1.1.1. Early Heart Morphogenesis and Endocardial Cushion Formation 1.1.2. Late Valve 19 1.2. VALVULAR DISORDERS 22 1.2.1. Myxomatous Valves 1.2.2. Mitral Prolapse 23 1.3. CELLULAR PROCESSES IN CARDIAC CUSHION MORPHOGENESIS.........24 1.3.1. Epithelial to Mesenchymal Transition (EMT) 24 1.3.2. Invasion 25 1.3.3. Proliferation 26 1.3.4. Apoptosis 1.4. SIGNAL TRANSDUCTION DURING 27 1.4.1. Extracellular Matrix 1.4.2. TGFβ/BMP Signaling 29 1.4.3. Vascular Endothelial Growth Factor 31 1.4.4. ErbB Ligands Receptors
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