Direct Allylic Amination of Allylic Alcohol Catalyzed by Palladium Complex Bearing Phosphine-Borane Ligand.
作者： Goki Hirata , Hideaki Satomura , Hidenobu Kumagae , Aika Shimizu , Gen Onodera
DOI: 10.1021/ACS.ORGLETT.7B03023
关键词: Allylic rearrangement 、 Chemistry 、 Electrophile 、 Organic chemistry 、 Palladium 、 Nucleophile 、 Medicinal chemistry 、 Borane 、 Catalysis 、 Amination 、 Phosphine
摘要: The direct electrophilic, nucleophilic, and amphiphilic allylations of allylic alcohol by use a palladium catalyst organometallic reagents such as organoborane organozinc has been developed. phosphine–borane compound works the effective ligand for palladium-catalyzed amination alcohol. Thus, with secondary amines, reaction was completed in only 1 h, even at room temperature.
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