BOVINE LEUKAEMIA VIRUS AND ENZOOTIC BOVINE LEUKOSIS

摘要: Infection of bovines with bovine leukaemia virus (BLV) manifests itself in either two ways: 30-70% carriers develop persistent lymphocytosis (PL), the viral genome integrated at a large number different sites DNA affected B-lymphocytes, without causing any chromosomal abnormalities. Only 0,1-10% lymphoid tumours, which also consist B-lymphocytes. In contrast to PL, however, they are mono- or oligoclonal origin terms integration site, is characteristic for each tumour. All cells contain one more copies genome, aberrations common and if deletions present invariably found 5'-half sequence. both types transcription repressed vivo, but transient production can be induced vitro detected by means syncytia induction haemagglutination. vivo some unknown cell suggested presence high antibody titres infected animals, especially against envelope glycoprotein gp51. This various techniques such as immunodiffusion, radioimmune assay ELISA. Monoclonal antibodies gp51 have revealed 8 epitopes, 3 recognized neutralizing cytolytic antibody. The BLV about 9 kb size, been cloned, information obtained on its molecular structure function discussed. It codes least 4 non-glycosylated 2 glycoproteins. Of special interest recently discovered serological relationship between proteins those human T-cell virus. functional role leukaemogenesis largely unknown. seems necessary maintenance transformed state, not continuous expression nor an LTR-mediated promotion cellular genes. No oncogene carried Although leukosis major economic importance, eradication desirable feasible countries relatively low incidence, testing elimination. For endemic situations vaccination would preferable, distinct possibilities exist development based vaccines.