Functional fluxolipidomics of polyunsaturated fatty acids and oxygenated metabolites in the blood vessel compartment.

摘要: Synthesis of bioactive oxygenated metabolites polyunsaturated fatty acids and their degradation or transformation products are made through multiple enzyme processes. The kinetics the enzymes responsible for different steps known to be quite diverse, although not precisely determined. location biosynthesis is diverse as well. Also, biological effects primary secondary products, life span often completely different. Consequently, phenotypes cells in response these lipid mediators must then depend on concentrations at a given time. This demands fluxolipidomics approach that can defined mediator lipidomics, with all measurements done function time compartments. review points out what known, even qualitatively, blood vascular compartment arachidonic acid number other from nutritional value. functional consequences especially taken into consideration.