Noncytotoxic, antitumor polysaccharides.

摘要: Publisher Summary This chapter provides an overview of the available information on host-mediated, antitumor action noncytotoxic polysaccharides extracted from different botanical sources. Serratia marcescens polysaccharide has been reported to be active against a number tumors, such as Sarcoma 180, Ehrlich carcinoma, Guerin M-1, and Walker carcinosarcoma. Navashin coworkers later found that animals develop resistance this polysaccharide, continued administration is without effect. However, if given periodically, increase in activity diminution toxicity are observed. Polysaccharide complexes Escherichia co1i , Staphylococcus aureus Streptococcus Klebsiella Pseudomonas Acetobacter xylinum Proteus vulgaris others solid tumors. Moreover, crude, fungal extracts fungi experimental and—in some cases—they showed definite palliative non-operable, human The so far examined, although strongly suppressing transplanted do not seem eligible for clinical trial cancer therapy. Therefore, search new more antitumor-active stands challenge further studies polysaccharides.