Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA-PEG nanoparticles.
作者： Serena Pillozzi , Serena Pillozzi , Mirko Severi , Alessandro Pratesi , Lorenzo Antonuzzo
DOI: 10.1007/S10534-021-00313-0
关键词: Auranofin 、 Cancer cell 、 Cancer research 、 Cytotoxic T cell 、 Protein kinase B 、 Signal transduction 、 Chemistry 、 Apoptosis 、 Autophagy 、 In vitro
摘要: Chloro(triethylphosphine)gold(I), (Et3PAuCl hereafter), is an Auranofin (AF)-related compound showing very similar biological and pharmacological properties. Like AF, Et3PAuCl exhibits potent antiproliferative properties in vitro toward a variety of cancer cell lines promising anticancer drug candidate. We wondered whether encapsulation might lead to improved profile also considering the likely reduction unwanted side-reactions that are responsible for adverse effects inactivation. was encapsulated biocompatible PLGA-PEG nanoparticles (NPs) new formulation evaluated colorectal HCT-116 cells comparison free gold complex. Notably, (nano-Et3PAuCl hereafter) mostly retains cellular complex elicits even greater cytotoxic (CRC) cells, mediated by apoptosis autophagy. Moreover, remarkable inhibition two crucial signaling pathways, i.e. ERK AKT, nano-Et3PAuCl, clearly documented. The implications these findings discussed.
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